Sebastian Hiller
Sebastian Hiller graduated in 2002 from ETH Zurich, Switzerland. He then did his PhD in the group of Kurt Wüthrich at ETH Zurich, where he developed advanced solution NMR methods to characterize folded and unfolded forms of globular proteins. As a postdoctoral researcher in the laboratory of Gerhard Wagner at Harvard Medical School, Boston, USA, he determined the de novo structure of the human mitochondrial voltage-dependent anion channel by solution NMR spectroscopy. In 2010, Sebastian Hiller received an SNSF professorship at the Biozentrum Basel to start his independent research group and was promoted in 2015 to associate professor. His research group applies advanced solution NMR methods integrated broadly with other structural biology and biophysics techniques, to unravel molecular mechanisms of biomacromolecules at the atomic level. Key topics are the elucidation of chaperone–client complexes at atomic resolution and the elucidation of the biophysical principles underlying their function; the mechanisms of folding and insertion of membrane proteins into the bacterial outer membrane and its inhibition by novel antibiotics; the structural biology of inflammasome-mediated pathways of the innate immune response; and dynamic mechanisms of kinase regulation and interaction with their substrates. Sebastian Hiller’s work was rewarded with the ERC starting grant, the EMBO young investigator award and the ICMRBS Founders’ medal.
Abstracts this author is presenting: