Thursday, 12th June The 6th Prato Conference on Pore Forming Proteins 2025

• Untangling the mysteries of black widow spider venom: structural and mechanistic basis of latrotoxin pore formation - Christos CG Gatsogiannis

• Aerolysin Nanopore: structural characterization in membrane mimics and novel single-molecule sensing applications - Jana Susanne Anton
• Structural insights into Tpp2-mediated mosquito control: receptor engagement with Cqm1 - Bradley Spicer
• Vpb4 proteins: PA-like proteins forming simple pores - Colin Berry

• Gasdermin pore mediates unconventional cytokine secretion and pyroptosis - Feng Shao

• Perforin-2 and its unusual mechanism of pore formation in dendritic cells - Patrycja Kozik

• Acidic pH can attenuate immune killing through inactivation of perforin - Adrian Hodel

• Are Lysosomal Storage Diseases Cryptic Cases of Cytotoxic Lymphocyte Deficiency? - Ilia Voskoboinik

• The structural basis of perforin and perforin-2 oligomerisation - Josh Benton
• Role of the acylated segment in folding and membrane penetration  of Bordetella pertussis adenylate cyclase toxin-hemolysin - Peter Sebo

• Membrane sphingolipid receptors are crucial for the formation of aegerolysin-based cytolytic complexes - Larisa Lara Popošek
• Tracking Apoptosis: EryA-mCherry as a Novel Biomarker for Surface-Exposed Cardiolipin in Mammalian Cells - Luka Žeželj
• The biological role of conoporins, actinoporin-like pore-forming toxins from cone snails - Matija Ruparčič
• Stabilization of bryoporin nanopores with non-canonical amino acids for use in nanopore sensing - Gregor Spruk
• Investigate the Pore-forming Mechanism of Plasmodium Perforin-like Protein 2 - Yu Zhang
• The role of human MPEG1 in severe Staphylococcus aureus infections - Ruben D. Siemerink
• Structural and functional insights into the Pseudomonas putida pore-forming toxin Tke5 - Maialen Zabala Zearreta
• Determining Vip3A Pore Behaviour and Electrophysiological Properties - Adam Cutts
• Cleavage-independent activation of ancient eukaryotic gasdermins and structural mechanisms - Yanjie Hou
• The structure of Vpb4. An independent pore forming protein from the binary toxin family, Bacterial Exotoxin B protein - Michelle A Dunstone
• Structural-functional characterization of Clostridium perfringens β-toxin interaction with its cellular receptor - Faezeh Farhoosh

• Recent applications of engineered nanopores - Hagan Bayley

• Real-Time Single-Cell Profiling with Interfacial Nanopores - Morteza Aramesh
• Tailoring Synthetic Alpha-Helical Pores for Enhanced Detection of Pathological Proteins - Varsha Shaji
• Mechanisms of RCD-1 pore formation and membrane bending - Fang Jiao

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Via Pomeria, 64, 59100 Prato PO, Italy

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